CALL FOR PRICING! Amoxicillin trihydrate is relatively stable in the
presence of gastric acid. After oral administration it is about
74-92% absorbed in humans and animals (monogastric). Food will decrease
the rate but not the extent of oral absorption and many clinicians
suggest giving the drug with food particularly if there is concomitant
associated GI distress. Amoxicillin serum levels will generally be
1.5-3 times greater than those of ampicillin after equivalent oral doses
Amoxicillin is eliminated primarily through renal mechanisms principally
by tubular secretion but some of the drug is metabolized by hydrolysis
to penicilloic acids (inactive) and then excreted in the urine.
Elimination half-lives of amoxicillin have has been reported as 45-90
minutes in dogs and cats and 90 minutes in cattle. Clearance is
reportedly 1.9 ml/kg/min in dogs.